
Can psychedelics improve your mental health?
Drs Chris and Xand van Tulleken explore the use of psychedelics to help treat clinical depression in patients where other treatments have failed.
Welcome to What’s Up Docs?, the podcast where doctors and identical twins Chris and Xand van Tulleken untangle the confusion around every aspect of our health and wellbeing.
This week, Chris and Xand meet Dr James Rucker, a consultant psychiatrist at King's College London who is leading the European arm of a global trial of a psychedelic called psilocybin in a study designed to treat people with severe depression for whom other pharmacological treatments have failed.
The use of psychedelics in both traditional medicinal and spiritual ceremonies dates back thousands of years and examples include peyote and ayahuasca from Central and South America, Iboga root from Central Africa and LSD, which is synthesised from a fungus found throughout Europe. As the number of clinical trials involving psychedelics increases, scientists are cautiously optimistic that they may be able to help with a range of conditions from eating disorders and anxiety to depression and addiction.
If you want to get in touch, you can email us at whatsupdocs@bbc.co.uk or WhatsApp us on 08000 665 123.
Presenters: Drs Chris and Xand van Tulleken
Guest: Dr James Rucker
Producer: Jo Rowntree
Executive Producer: Rami Tzabar
Editor: Kirsten Lass
Assistant Producer: Maia Miller-Lewis
Assistant Producer and Researcher: Emily Bird
Tech Lead: Reuben Huxtable
Social Media: Leon Gower
Digital Lead: Richard Berry
Composer: Phoebe McFarlane
Sound Design: Melvin Rickarby
At the ÃÛÑ¿´«Ã½:
Assistant Commissioner: Greg Smith
Commissioning Editor: Rhian Roberts
A Loftus Media production for ÃÛÑ¿´«Ã½ Radio 4
On radio
Broadcast
- Tue 30 Sep 2025 16:30ÃÛÑ¿´«Ã½ Radio 4
Podcast
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What's Up Docs?
Chris and Xand van Tulleken are on a mission to help us take better care of ourselves.